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J Med Microbiol. 1999 Mar;48(3):309-15.

Relationship between morphological changes and endotoxin release induced by carbapenems in Pseudomonas aeruginosa.

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Department of Bacteriology, Nagoya University School of Medicine, Japan.


The relationship between morphological changes and endotoxin release induced in vitro by carbapenems in a clinical isolate of Pseudomonas aeruginosa was examined. The time-course and magnitude of endotoxin release induced varied among imipenem, panipenem, meropenem and biapenem and related to the morphological changes caused by these agents which variously affected cell shape, cell-wall disintegration and cell lysis. The amount of endotoxin released by carbapenem-treated cells correlated with both the cell-wall morphology and bacterial shape immediately before lysis. Meropenem and biapenem caused markedly increased endotoxin release during cell lysis and cell-wall disintegration, whereas imipenem and panipenem caused much less release of endotoxin.

[Indexed for MEDLINE]

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