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Zh Vyssh Nerv Deiat Im I P Pavlova. 1999 Jan-Feb;49(1):96-105.

[The discriminative stimulus properties of naloxone during dissociative learning in a Y maze in morphine-dependent rats].

[Article in Russian]

Author information

1
Department of Psychopharmacology, Valdman Institute of Pharmacology, Pavlov State Medical University, St.-Petersburg.

Abstract

The study was dedicated to evaluation of discriminative stimulus properties of opiate withdrawal syndrome precipitated by naloxon. The possibility of naloxon-appropriate reaction significantly increased in a dose-dependent manner (0-1.0 mg/kg, ED50 = 0.03 mg/kg) and was observed during the period of morphine withdrawal (8-96 h, peak at 24 h). Naloxone stimulus effects were antagonized by morphine (10-100.mg/kg), thus providing the experimental evidence for competitive and saturatable nature of interaction with opiate receptors. The probability of naloxone-appropriate reaction decreased during administration of the conditioned stimulus associated with morphine injection. Ligands of peripheral opiate receptors failed to either substitute for naloxone (methylnaloxon, 0.1-3.0 mg/kg) or attenuate naloxone stimulus effects (loperamide, 1-30 mg/kg).

PMID:
10330710
[Indexed for MEDLINE]

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