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Zh Vyssh Nerv Deiat Im I P Pavlova. 1999 Jan-Feb;49(1):96-105.

[The discriminative stimulus properties of naloxone during dissociative learning in a Y maze in morphine-dependent rats].

[Article in Russian]

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Department of Psychopharmacology, Valdman Institute of Pharmacology, Pavlov State Medical University, St.-Petersburg.


The study was dedicated to evaluation of discriminative stimulus properties of opiate withdrawal syndrome precipitated by naloxon. The possibility of naloxon-appropriate reaction significantly increased in a dose-dependent manner (0-1.0 mg/kg, ED50 = 0.03 mg/kg) and was observed during the period of morphine withdrawal (8-96 h, peak at 24 h). Naloxone stimulus effects were antagonized by morphine (, thus providing the experimental evidence for competitive and saturatable nature of interaction with opiate receptors. The probability of naloxone-appropriate reaction decreased during administration of the conditioned stimulus associated with morphine injection. Ligands of peripheral opiate receptors failed to either substitute for naloxone (methylnaloxon, 0.1-3.0 mg/kg) or attenuate naloxone stimulus effects (loperamide, 1-30 mg/kg).

[Indexed for MEDLINE]

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