Send to

Choose Destination
Am J Hum Genet. 1999 Jun;64(6):1728-38.

Linkage-disequilibrium mapping of disease genes by reconstruction of ancestral haplotypes in founder populations.

Author information

Neurogenetics Laboratory and Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco, CA 94143, USA.


Linkage disequilibrium (LD) mapping may be a powerful means for genome screening to identify susceptibility loci for common diseases. A new statistical approach for detection of LD around a disease gene is presented here. This method compares the distribution of haplotypes in affected individuals versus that expected for individuals descended from a common ancestor who carried a mutation of the disease gene. Simulations demonstrate that this method, which we term "ancestral haplotype reconstruction" (AHR), should be powerful for genome screening of phenotypes characterized by a high degree of etiologic heterogeneity, even with currently available marker maps. AHR is best suited to application in isolated populations where affected individuals are relatively recently descended (< approximately 25 generations) from a common disease mutation-bearing founder.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center