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Curr Opin Microbiol. 1999 Apr;2(2):142-7.

Regulation by proteolysis: developmental switches.

Author information

1
Building 37, Room 2E18, Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892-4255, USA. susang@helix.nih.gov

Abstract

The energy-dependent proteases originally defined in Escherichia coli have proven to have particularly important roles in bacterial developmental systems, including sporulation in Bacillus subtilis and cell cycle in Caulobacter. Degradation of key regulatory proteins participates, with regulation of synthesis and activity of the regulators, to ensure tight control and, where required, irreversible commitment of the cell to specific developmental pathways.

PMID:
10322171
DOI:
10.1016/S1369-5274(99)80025-3
[Indexed for MEDLINE]

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