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Curr Opin Immunol. 1999 Apr;11(2):209-13.

Description and prediction of peptide-MHC binding: the 'human MHC project'.

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Institute of Medical Microbiology and Immunology, Panum Building 18.3.22, Blegdamsvej 3, 2200, Copenhagen N, Denmark.


MHC molecules are crucially involved in controlling the specific immune system. They are highly polymorphic receptors sampling peptides from the cellular environment and presenting these peptides for scrutiny by immune cells. Recent advances in combinatorial peptide chemistry have improved the description and prediction of peptide-MHC binding. It is envisioned that a complete mapping of human immune reactivities will be possible.

[Indexed for MEDLINE]

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