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Curr Opin Immunol. 1999 Apr;11(2):143-51.

B cell development: signal transduction by antigen receptors and their surrogates.

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Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.


Constitutive signal transduction by B cell antigen-receptors and/or their surrogates appears to be critical for progression through multiple developmental checkpoints and for survival of mature B cells in the periphery. Antigen-induced signaling via the B cell receptor can compensate for defects in constitutive signaling and initiates receptor editing, apoptosis and anergy in normal mice - purging the repertoire of autoreactive cells. Thus development and survival of mature B cells seem to require continuous receptor signaling of a defined amplitude.

[Indexed for MEDLINE]

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