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Curr Opin Genet Dev. 1999 Apr;9(2):199-205.

Nuclear compartments and gene regulation.

Author information

1
Swiss Institute for Experimental Cancer Research, Ch. des Boveresses 155, CH-1066, Epalinges s/Lausanne, Switzerland,

Abstract

Improvements in fluorescence microscopy have allowed us to explore the three-dimensional organization of the nucleus in ways that were impossible ten years ago, revealing subdomains or compartments within the nucleus defined by their enrichments of subsets of factors. Correlations have been drawn between the silencing of a gene and its proximity to a heterochromatic compartment or to the nuclear periphery. The application of genetics and high-resolution microscopy helps examine the creation, maintenance and impact of these compartments on gene expression.

PMID:
10322139
DOI:
10.1016/S0959-437X(99)80030-6
[Indexed for MEDLINE]

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