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Curr Opin Genet Dev. 1999 Apr;9(2):175-84.

Modifying chromatin and concepts of cancer.

Author information

1
Department of Biology 0347, University of California at San Diego, 2100A Pacific Hall, 9500 Gilman Drive, La Jolla, California 92093-0347, USA. sandij@biomail.ucsd.edu

Abstract

A wave of biochemical and genetic progress has identified proteins that influence transcription by modifying chromatin. Many such factors are broadly conserved and, strikingly, occur in human diseases as partners in chromosomal translocations. Understanding the function of these factors will be key to defining mechanisms of transcriptional regulation and understanding cancers linked to aberrant chromatin modification.

PMID:
10322138
DOI:
10.1016/S0959-437X(99)80027-6
[Indexed for MEDLINE]

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