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Chem Biol. 1999 May;6(5):R137-46.

Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site.

Author information

1
Center for Advanced Biotechnology and Medicine (CABM), Rutgers University Chemistry Department, 679 Hoes Lane, Piscataway, NJ 08854-5638, USA.

Abstract

Comparison of the recently solved structure of HIV-1 reverse transcriptase (RT)-DNA-dNTP ternary complex with the previously solved structure of RT-DNA binary complex suggests mechanisms by which the HIV-1 RT becomes resistant to nucleoside-analog inhibitors, drugs currently used in the treatment of AIDS.

PMID:
10322129
DOI:
10.1016/s1074-5521(99)80071-4
[Indexed for MEDLINE]
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