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Chem Biol. 1999 May;6(5):R129-36.

The PIK-related kinases intercept conventional signaling pathways.

Author information

1
Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Abstract

Early efforts to place the first cloned mammalian PIK-related kinase, FRAP, into a conventional membrane to nuclear pathway met with little success. More recent data suggest that members of the family of PIK-related kinases act as intracellular sensors that govern radial and horizontal pathways. These pathways can impinge upon classical membrane to nuclear pathways, as well as components of the cell-cycle machinery.

PMID:
10322127
DOI:
10.1016/S1074-5521(99)80070-2
[Indexed for MEDLINE]
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