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Brain Res Mol Brain Res. 1999 May 7;68(1-2):181-5.

Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures.

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Hospital Research Centre, Department of Neurology and Neurosurgery, McGill University, Verdun, Quebec, Canada.


Both apolipoprotein E (apoE) and amyloid peptides are associated with Alzheimer's disease (AD). Using primary hippocampal neurons, we demonstrate that apoE is capable of reducing potentially toxic extracellular amyloid peptides, likely through a receptor mediated mechanism. We hypothesize that isoform-specific differences in apoE-mediated amyloid clearance and intracellular accumulation may be responsible, at least in part, for the increased number of amyloid plaques observed in apoE epsilon4 allele AD individuals.

[Indexed for MEDLINE]

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