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Biochim Biophys Acta. 1999 May 5;1411(2-3):437-55.

Nitric oxide in septic shock.

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School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.


Septic shock is a major cause of death following trauma and is a persistent problem in surgical patients throughout the world. It is characterised by hypotension and vascular collapse, with a failure of the major organs within the body. The role of excessive nitric oxide (NO) production, following the cytokine-dependent induction of the inducible nitric oxide synthase (iNOS), in the development of septic shock is discussed. Emphasis is placed upon the signal-transduction process by which iNOS is induced and the role of NO in cellular energy dysfunction and the abnormal function of the cardiovascular system and liver during septic shock.

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