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Biochim Biophys Acta. 1999 May 5;1411(2-3):401-14.

Nitric oxide and cell death.

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1
Department of Biochemistry, University of Otago, Box 56, Dunedin, New Zealand. murphy@sanger.otago.ac.nz

Abstract

Nitric oxide (NO) has several essential roles in mammals, but unregulated NO production can cause cell death through oxidative stress, disrupted energy metabolism, DNA damage, activation of poly(ADP-ribose) polymerase, or dysregulation of cytosolic calcium. Such disturbances can lead to either apoptotic or necrotic cell death, depending on the severity and context of the damage. Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration.

PMID:
10320672
[Indexed for MEDLINE]
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