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J Hum Genet. 1999;44(3):185-9.

Cloning, tissue expression, and chromosomal assignment of human MRJ gene for a member of the DNAJ protein family.

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1
Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan.

Abstract

The DnaJ protein family consists of proteins with a highly conserved amino acid stretch called the "J-domain". A cDNA clone encoding a new protein with a J-domain was isolated from a human fetal brain cDNA library. This new member of the DnaJ family of 241 amino acid residues showed 94% identity with mouse Mrj (accession number, AF035962) and 71% identity with mouse Msj-1 (accession number, U95607) along its entire sequence. Reverse transcription-coupled polymerase chain reaction (RT-PCR) analysis showed the messenger RNA was ubiquitously expressed in various human tissues. The chromosomal location of the gene was determined by PCR-based analyses with both a human/rodent monochromosomal hybrid cell panel and a radiation hybrid panel to map on chromosome 11q25 region.

PMID:
10319584
DOI:
10.1007/s100380050139
[Indexed for MEDLINE]
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