Experiments in random-bred and BALB/c white mice inoculated intraperitoneally with street virus, in Syrian hamsters inoculated intramuscularly with fixed viruses as well as experiments reproducing abortive rabies in 99-100% in random-bred white mice inoculated intramuscularly with fixed virus (ERA strain) showed that in the abortive infection the intensity of virus multiplication in the brain is lower than that in fatal infection, the differences being statistically significant. It was found out that from onset of signs of the disease interferon appeared to have no influence on the outcome of infection.