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Clin Exp Dermatol. 1999 Jan;24(1):16-8.

Diffuse cutaneous mastocytosis responding to cyproheptadine.

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Department of Dermatology, Osaka Medical College, Osaka, Japan.


A 3-month-old male infant was referred to our department with a generalized brown, thickened leathery skin and blisters which had been present since birth; the blisters developed recurrently at sites of minor trauma, healing without scar formation, although Darier's sign was positive. Microscopically, biopsy specimens showed a dense dermal band-like infiltrate with mast cells, whereas a biopsy from a vesicle showed subepidermal bulla formation. Physical examination did not reveal any systemic involvement with mastocytosis and the patient was treated with cyproheptadine, which has considerable anti-serotonin activity and, interestingly, reduced the degree of blistering; this treatment might therefore be tried in other cases.

[Indexed for MEDLINE]

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