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Clin Exp Dermatol. 1998 Sep;23(5):222-4.

Vaccine-induced necrobiotic granuloma.

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Department of Dermatology, C.M.C. Hospital, Vellore, India.


We report two cases of necrobiotic palisaded granulomas which developed at the site of intradermal hepatitis B vaccination. To the best of our knowledge, this kind of reaction has not been reported previously.

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