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Transplantation. 1999 Apr 27;67(8):1087-93.

Portopulmonary hypertension and the liver transplant candidate.

Author information

1
Department of Surgery, Georgetown University Medical Center, Washington, DC 20007, USA. kuop@gunet.georgetown.edu

Abstract

The management of the liver transplant (OLT) candidate with portopulmonary hypertension (PPHTN) has dramatically changed in the past 3 years. Careful preoperative evaluation with functional characterization of right ventricular function plays a critical role. The pulmonary vascular response to epoprostenol infusion serves as a deciding factor for OLT candidacy. Careful perioperative attention to avoid right ventricular failure from acutely elevated pulmonary artery pressures or sudden increases in right ventricular preload is a key physiologic tenet of management. With increased surgical expertise, anesthetic sophistication, and availability of epoprostenol, PPHTN is no longer considered an absolute contraindication for OLT.

[Indexed for MEDLINE]

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