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Biochemistry (Mosc). 1999 Apr;64(4):468-72.

Molecular mechanisms of the antiproliferative effect of vitamin K3 on Jurkat cells.

Author information

1
Engelhardt Institute of Molecular Biology, Russia Academy of Sciences, Moscow, 117984, Russia. azel@genome.eimb.relarn.ru.

Abstract

Molecular mechanisms of the antiproliferative effect of vitamin K3 (sodium 2,3-dihydro-2-methyl-1,4-naphthoquinone-2-sulfonate) were studied on a human T-lymphoma model (Jurkat cell line). It is shown that a short-term treatment of the cells with vitamin K3 damages their genomic DNA. Further culturing of the cells in the presence of vitamin K3 decreases the expression of the c-myc gene, inhibits the activity of DNA-dependent DNA-polymerases, and leads to the subsequent development of apoptosis. Combined exposure to vitamin K3 and azidothymidine has a synergistic antiproliferative effect.

PMID:
10231603
[Indexed for MEDLINE]

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