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Bioorg Med Chem Lett. 1999 Apr 5;9(7):967-72.

Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists.

Author information

1
DuPont Pharmaceuticals Company, Chemical and Physical Sciences, Wilmington, DE 19880-0500, USA.

Abstract

A series of purin-8-ones was prepared and discovered to have excellent binding affinity to the CRH-R1 receptor. Structure-activity studies focused on amine side-chain optimization, urea substitution and pyridyl isostere incorporation. Thus, the highly potent purin-8-ones show promise as a new class of potential anxiolytics and/or antidepressants.

PMID:
10230622
DOI:
10.1016/s0960-894x(99)00108-0
[Indexed for MEDLINE]

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