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J Sports Med Phys Fitness. 1999 Mar;39(1):1-11.

Immune responses to training: how critical is training volume?

Author information

1
Graduate Programme in Exercise Sciences, University of Toronto, Canada.

Abstract

BACKGROUND:

If the volume of training undertaken is sufficient to induce a negative energy balance, the anticipated benefit of an enhanced immune response may be reduced or lost.

METHODS:

33 sedentary but healthy male volunteers aged 19-29 years, recruited from the university community. A peak oxygen intake measurement (cycle ergometer) and a 60-min exercise challenge at 60% of aerobic power were performed before and after 12 wk of treatment. Total leukocytes, subsets, CD3+, CD4+, CD8+, CD16+, CD19+, and CD25+ counts (FACScan), cytolytic activity (51Cr release) and cell proliferation (PHA and PWM) were measured, with subjects assigned arbitrarily to one of three groups: light training (18 subjects, aerobic exercise at 70-85% HRmax 3 times/wk), moderate training (9 subjects, similar programme 4-5 times/wk) and control (6 subjects).

RESULTS:

Groups were initially well-matched in physical and physiological terms. Training increased aerobic power (8%, light, 21% moderate training), with a loss of body mass and fat in the moderate training group. Controls showed no changes. Resting CD16+ counts increased by 27% (light training) and CD16+ CD56+ counts by 21% (moderate training), with less post-exercise suppression of counts than at recruitment. Light training also decreased CD3+ and CD4+ counts without changing the CD4+/CD8+ ratio. Moderate training decreased resting CD19+ count.

CONCLUSIONS:

From the viewpoint of immune function, the optimal training regimen is of low volume. Moderate training sufficient to induce a negative energy balance yields a smaller increase in numbers of non-MHC-restricted cytotoxic cells, and carries the negative consequence of diminished B cell counts.

PMID:
10230161
[Indexed for MEDLINE]

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