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JAMA. 1999 Apr 28;281(16):1493-7.

Epidemic serogroup B meningococcal disease in Oregon: the evolving epidemiology of the ET-5 strain.

Author information

1
Oregon Health Division, Portland, USA.

Abstract

CONTEXT:

In 1993, Oregon's incidence of serogroup B meningococcal disease began to rise because of a highly clonal group of strains designated enzyme type 5 (ET-5), the first such increase observed in the United States.

OBJECTIVE:

To evaluate the impact that the ET-5 strain has had on the epidemiology of meningococcal disease in Oregon.

DESIGN AND SETTING:

Epidemiologic analysis of surveillance data on Oregon meningococcal disease cases from 1987 through 1996 and multilocus enzyme electrophoresis typing of serogroup B isolates from June 1993 through April 1995 and from April through June 1996.

PATIENTS:

A total of 836 persons with invasive meningococcal disease.

MAIN OUTCOME MEASURES:

Disease frequency and clonality of strains.

RESULTS:

Serogroup B disease incidence rates more than doubled from the preepidemic period in 1987-1992 (1.0 case per 100000 population) to the recent epidemic period in 1995-1996 (2.2 cases per 100000). The age-specific incidence rate of serogroup B disease among those 15 through 19 years old increased 13-fold between the preepidemic period (0.5 case per 100000) and 1995-1996 (6.4 cases per 100000). However, the proportion of cases with meningococcemia and the case-fatality rate did not change. Of 99 Neisseria meningitidis isolates obtained from 1993-1995, 88 (89%) belonged to the ET-5 complex. Of these, 69 (78%) were a single clone, designated 301. Of 20 serogroup B isolates from 1996, 18 (90%) belonged to the ET-5 complex; 17 (94%) were the 301 clone.

CONCLUSION:

Serogroup B meningococcal disease incidence continues at high levels in Oregon with increasing predominance of the ET-5 clonal strains.

PMID:
10227318
[Indexed for MEDLINE]

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