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Blood Press Monit. 1996 Jun;1(3):251-254.

Predictive power of screening blood pressure, ambulatory blood pressure and blood pressure measured at home for overall and cardiovascular mortality: a prospective observation in a cohort from Ohasama, northern Japan.

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The Second Department of Medicine, Tohoku University School of Medicine, Sendai, Japan.



To investigate the risks of high and low blood pressure levels determined by ambulatory blood pressure monitoring and home blood pressure measurements.


A long-term prospective study of all-cause mortality and cardiovascular mortality has been conducted in Ohasama, Japan since 1987.


The Cox proportional hazards model after adjusting for age and sex demonstrated that, during a 5-year follow-up period involving 893 of the subjects aged 50 years or more in this cohort, those with the lowest quintile of ambulatory blood pressure levels exhibited a significantly higher hazard ratio for cardiovascular and for all-cause mortality. During the same follow-up period, of 1226 subjects aged 50 years and more, those with the lowest and highest quintiles of home blood pressure levels demonstrated a significantly higher hazard ratio with respect to cardiovascular and all-cause mortality (i.e., a J-shaped relationship).


These results suggest that there is a significant risk associated with low blood pressure levels, which can be determined by ambulatory and home blood pressure measurements, but not by casual blood pressure measurements.


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