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Curr Biol. 1999 Apr 22;9(8):R305-8.

Molecular chaperones: How J domains turn on Hsp70s.

Author information

1
Département de Biochimie Médicale, CMU-Université de Genève, 1 rue Michel-Servet, 1211 Genève 4, Switzerland. William.Kelley@medecine.unige.ch

Abstract

Molecular chaperones of the heat shock protein 70 (Hsp70) variety facilitate protein folding and assembly. They are assisted in this role by their Hsp40 partners, and recent studies have shed new light on how the 'J domains' of these 'cochaperones' activate substrate binding by Hsp70 molecules.

PMID:
10226023
DOI:
10.1016/s0960-9822(99)80185-7
[Indexed for MEDLINE]
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