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FEBS Lett. 1999 Apr 16;449(1):7-11.

The diversity of the lipoxygenase family. Many sequence data but little information on biological significance.

Author information

1
Institute of Biochemistry, University Clinics (Charité), Humboldt University, Berlin, Germany. hartmut.kuehn@rz.hu-berlin.de

Abstract

Lipoxygenases form a family of lipid peroxidising enzymes, which oxygenate free and esterified polyenoic fatty acids to the corresponding hydroperoxy derivatives. They are widely distributed in both the plant and animal kingdoms. During the last couple of years more and more lipoxygenase isoforms have been discovered but for most of them the biological significance remains unclear. This review attempts to classify the currently known mammalian lipoxygenase isoforms and critically reviews the concepts for their biological importance.

PMID:
10225417
DOI:
10.1016/s0014-5793(99)00396-8
[Indexed for MEDLINE]
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