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Antimicrob Agents Chemother. 1999 May;43(5):1274-6.

Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide.

Author information

1
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.

Abstract

Both linear and cyclic derivatives of the cyclic 12-amino-acid antimicrobial peptide bactenecin were designed based on optimization of amphipathicity and charge location. In general, increasing the number of positive charges at the N and C termini and adding an extra tryptophan residue in the loop not only increased the activities against both gram-positive and gram-negative bacteria but also broadened the antimicrobial spectrum.

PMID:
10223951
PMCID:
PMC89258
[Indexed for MEDLINE]
Free PMC Article

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