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Dis Colon Rectum. 1999 Mar;42(3):334-6.

Protective effect of appendectomy on the development of ulcerative colitis: matched, case-control study.

Author information

1
University Department of Surgery, Christchurch Hospital and Medical School, New Zealand.

Abstract

PURPOSE:

Appendectomy and cigarette smoking have been suggested to reduce the chance of developing ulcerative colitis. A case-control study was undertaken to determine the relative incidence of appendectomy in patients with ulcerative colitis.

METHODS:

This case-control study examined the incidence of appendectomy in patients with ulcerative colitis and patients attending an orthopedic outpatient clinic.

RESULTS:

Of 100 patients with ulcerative colitis, 75 pairs were matched for age, gender, and cigarette smoking. The ulcerative colitis group had an appendectomy rate of 8 percent (6/75), compared with 21 percent in the control group (P = 0.018). The odds ratio was 3.5 (95 percent confidence interval, 1.15-10.6).

CONCLUSIONS:

No previous study has examined the effect of appendectomy, controlling for cigarette smoking. This study confirms that appendectomy protects against or reduces the chance of development of ulcerative colitis. A possible immunological explanation for this effect is advanced.

PMID:
10223752
DOI:
10.1007/bf02236349
[Indexed for MEDLINE]

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