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Int Clin Psychopharmacol. 1999 Mar;14(2):133-7.

Clinical trials of new antipsychotics: a critical appraisal.

Author information

1
Laboratory of Epidemiology and Social Psychiatry, WHO Collaborating Centre for Research and Training in Mental Health, Mario Negri Institute for Pharmacological Research, Milan, Italy. barbui@irfmn.mnegri.it

Abstract

In recent years the efficacy of new antipsychotics has been investigated through a number of randomized controlled trials. This paper considers some methodological flaws that affect these studies and proposes possible solutions. The final goal is the implementation of a new generation of trials with the aim of demonstrating superiority of effect of the new antipsychotic over the reference one.

[Indexed for MEDLINE]

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