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Scand J Immunol. 1999 Apr;49(4):362-6.

The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity.

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Hospital Universitari Germans Trias i Pujol, Departament de Genètica i Microbiologia, Facultat de Medicina, Universitat Autònoma de Barcelona, Catalonia, Spain.


The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-gamma response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.

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