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Arch Esp Urol. 1999 Mar;52(2):169-70.

[Granular cell tumor of the scrotum with high pseudoepitheliomatous hyperplasia].

[Article in Spanish]

Author information

1
Servicio de Anatomía Patológica, Hospital de la Merced, Osuna, Sevilla, España.

Abstract

OBJECTIVE:

To report a rare case of scrotal granular cell tumor.

METHODS:

A 19-year-old man presented with a nodule on the scrotum, 2 cm in diameter. It had been present for months and was covered with ulcerated epidermis. The tumor was resected.

RESULTS:

The histological study disclosed a neoplasm composed of polygonal cells with cytoplasmic granules and pseudoepitheliomatous hyperplasia of the overlying skin. Immunohistochemically, the cells showed a strong positivity for S100 protein and vimentin. The proliferation index (ki 67) was low in its cells, but high in the overlying hyperplasic epidermal cells.

CONCLUSIONS:

To our knowledge, this is the second case of scrotal granular cell tumor reported. The case described herein has the unique feature of severe overlying pseudoepitheliomatous hyperplasia. S100 positivity supports a neurogenic differentiation.

PMID:
10218281
[Indexed for MEDLINE]

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