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Trends Microbiol. 1999 Apr;7(4):172-6.

Bordatella pertussis adenylate cyclase: a toxin with multiple talents.

Author information

1
Dept of Biochemistry and Molecular Genetics, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.

Abstract

Bordetella pertussis secretes a calmodulin-activated adenylate cyclase toxin (CyaA) that is able to deliver its amino-terminal catalytic domain into the cytosol of eukaryotic cells. The novelty of the structural organization and conformational flexibility of the CyaA catalytic domain has opened up the way for exploiting this protein as a tool for several biological applications, including epitope delivery, protein targeting and characterization of protein-protein interactions.

PMID:
10217833
[Indexed for MEDLINE]

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