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Trends Microbiol. 1999 Apr;7(4):160-5.

Apoptosis: an innate immune response to virus infection.

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Dept of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.


Viruses can induce apoptosis of infected cells either directly, to assist virus dissemination, or by inadvertently triggering cellular sensors that initiate cell death. Cellular checkpoints that can function as 'alarm bells' to transmit pro-apoptotic signals in response to virus infections include death receptors, protein kinase R, mitochondrial membrane potential, p53 and the endoplasmic reticulum.

[Indexed for MEDLINE]

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