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Trends Microbiol. 1999 Apr;7(4):144-9.

HIV-1 attachment: another look.

Author information

1
Centre d'Immunologie de Marseille-Luminy, 163 Avenue de Luminy, Case 906, 13288 Marseille Cedex 9, France.

Abstract

HIV-1 attachment to host cells is generally considered to take place via high-affinity binding between CD4 and gp120. However, the binding of virion-associated gp120 to cellular CD4 is often weak, and most cell types that are permissive for HIV-1 infection express little CD4. Thus, other interactions between the virion and the cell surface could dominate the attachment process.

PMID:
10217828
DOI:
10.1016/s0966-842x(99)01474-2
[Indexed for MEDLINE]

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