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J Nat Prod. 1999 Apr;62(4):587-9.

The antiproliferative effect of acridone alkaloids on several cancer cell lines.

Author information

1
National Institute of Fruit Tree Science, Okitsu, Shimizu, Shizuoka, 424-0204, Japan.

Abstract

Fifteen acridone alkaloids were examined for their antiproliferative activity toward monolayers and suspension of several types of cancer and normal human cell lines. As a result, atalaphyllidine (9), 5-hydroxy-N-methylseverifoline (11), atalaphyllinine (12), and des-N-methylnoracronycine (13) showed potent antiproliferative activity against tumor cell lines, whereas they have weak cytotoxicity on normal human cell lines. The structure-activity relationship established from the results revealed that a secondary amine, hydroxyl groups at C-1 and C-5, and a prenyl group at C-2 played an important role for antiproliferative activities of the tetracyclic acridones.

PMID:
10217715
DOI:
10.1021/np980504z
[Indexed for MEDLINE]

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