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Neurology. 1999 Apr 12;52(6):1285-8.

Thrombotic thrombocytopenic purpura: brain CT and MRI findings in 12 patients.

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Department of Neurology, University at Buffalo (SUNY) School of Medicine and Biomedical Sciences, Dent Neurologic Institute and Millard Fillmore Hospital, NY, USA.


Clinical-neuroimaging analysis of 12 thrombotic thrombocytopenic purpura (TTP) patients revealed a variety of brain lesions. These included reversible cerebral edema lesions with MRI features of reversible posterior leukoencephalopathy syndrome (RPLS). Most of the RPLS patients had hypertension and renal dysfunction, suggesting RPLS due to hypertensive encephalopathy. Prompt treatment usually led to neurologic recovery and disappearance of edematous lesions. Those with infarcts or hematomas had a poorer outcome. TTP should be added to the expanding spectrum of RPLS and hypertensive encephalopathy.

[Indexed for MEDLINE]

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