Format

Send to

Choose Destination
Cancer Lett. 1999 Feb 8;136(1):83-7.

N-acetyltransferase 1 genetic polymorphism influences the risk of prostate cancer development.

Author information

1
Department of Pathology, Mie University School of Medicine, Tsu, Japan. tome@doc.medic.mie-u.ac.jp

Abstract

The potential involvement of N-acetyltransferase 1 (NAT1) genetic polymorphisms in prostate cancer (PCa) patients was analyzed in 101 patients with PCa and 97 controls with no incidental malignancy. Identification of NAT1*10, the variant allele associated with the rapid acetylator phenotype was by allele-specific polymerase chain reaction (PCR). When the NAT1*10 heterozygote and other genotypes without NAT1*10 allele were considered as low risk genotypes, NAT1*10/NAT1*10 had a significantly higher risk of PCa (OR = 2.4, 95% CI; 1.0-5.6). If our preliminary results can be confirmed in a larger population, it may be a useful marker for PCa risk.

PMID:
10211944
DOI:
10.1016/s0304-3835(98)00311-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center