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Neoplasma. 1998;45(6):369-72.

Estimation of oncostatin M (OSM) secretion by peritoneal macrophages with regard to the progression of transplantable melanomas.

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Department of Embryology, Medical University, Gdańsk, Poland.


The authors have studied the influence of two kinds of transplantable melanomas on the secretion of oncostatin M (OSM) and total proteins by peritoneal macrophages. Culture supernatant samples were tested by ELISA. The macrophages of melanoma-bearing animals released a lower amount of OSM than those of the controls. At the same time the results showed statistically significant increase of protein content in the supernatants of cultured macrophages from melanoma-bearing hamsters in comparison with the controls. However, it has not been possible to demonstrate any relationship between melanoma progression and changes in the secretion of OSM by peritoneal macrophages.

[Indexed for MEDLINE]

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