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Mol Microbiol. 1999 Mar;31(6):1611-8.

Termination of DNA replication of bacterial and plasmid chromosomes.

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Department of Structural Biology, Abbott Laboratories, Abbott Park, IL 60064, USA.


Sequence-specific replication termini occur in many bacterial and plasmid chromosomes and consist of two components: a cis-acting ter site and a trans-acting replication terminator protein. The interaction of a terminator protein with the ter site creates a protein-DNA complex that arrests replication forks in a polar fashion by antagonizing the action of the replicative helicase (thereby exhibiting a contrahelicase activity). Terminator proteins also arrest RNA polymerases in a polar fashion. Passage of an RNA transcript through a terminus from the non-blocking direction abrogates replication termination function, a mechanism that is likely to be used in conditional termini or replication check points.

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