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Mol Microbiol. 1999 Mar;31(6):1603-9.

Mycobacterium tuberculosis phagosome.

Author information

1
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA. Deretic@umich.edu

Abstract

The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment-specialized regulators of vesicular trafficking and other parts of membrane fusion machinery are likely to play a role in these processes. Here we summarize the emerging view of mycobacterial phagosome maturation arrest in the context of the dynamic processes of intracellular membrane trafficking.

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