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Tuber Lung Dis. 1997;78(5-6):257-61.

Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice.

Author information

1
Department of Microbiology, Colorado State University, Fort Collins 80523, USA.

Abstract

OBJECTIVE:

Use gene disrupted mice to examine the possible role of secretory antibody on resistance to re-exposure to pulmonary tuberculosis.

DESIGN:

Mice deficient in B cells due to targeted gene disruption were infected by aerosol exposure with Mycobacterium tuberculosis. A further set were identically exposed then given isoniazid to clear the infection and establish a state of memory immunity.

RESULTS:

Control of the aerosol infection and generation of gamma interferon proceeded in a similar manner in both naive and memory immune mice, regardless of B cell deficiency.

CONCLUSIONS:

The absence of antibody responses did not affect the course of infection, thus confirming the classical literature that antibody plays no significant protective role.

PMID:
10209680
[Indexed for MEDLINE]

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