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Curr Opin Cell Biol. 1999 Apr;11(2):267-73.

Regulating the onset of mitosis.

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Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.


In eukaryotes, G2/M progression is mediated by activation of mitosis promoting factor (MPF). To ensure faithful chromosome segregation, the activity of key mitotic inducers and inhibitors are coupled with chromosome replication, spindle pole duplication, morphogenesis, and DNA damage. Evidence gathered in the past two years has underscored the importance of positioning MPF and its regulators in the proper place at the proper time to ensure orderly progression through the G2/M transition. Altering the spatial organization of G2/M regulators also contributes to prevention of mitosis following DNA damage.

[Indexed for MEDLINE]

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