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Curr Opin Cell Biol. 1999 Apr;11(2):203-10.

Costimulatory regulation of T cell function.

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Howard Hughes Medical Research Institute, Cancer Research Laboratory, Department of Molecular and Cellular Biology, 415 Life Science Addition, University of California, Berkeley, CA 94720, USA.


During the past several years, the critical role of costimulatory molecules in regulating T cell responses has been demonstrated. Costimulatory molecule CD28 enhances whereas CTLA-4 downmodulates T cell responses. An understanding of the integration of the signals mediated by costimulatory molecules and the T cell receptor at the cellular and molecular levels is just beginning to be achieved.

[Indexed for MEDLINE]

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