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Curr Opin Cell Biol. 1999 Apr;11(2):226-32.

Multiple signals converging on NF-kappaB.

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Signal Pharmaceuticals Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA.


The recent identification of molecular components of the signal transduction pathway regulating activation of nuclear factor-kappaB (NF-kappaB) in response to cytokines such as tumor necrosis factor alpha and interleukin-1beta allows the evaluation of how other diverse stimuli impinge on the NF-kappaB activation pathway. These studies suggest a basis for specificity in activation of specific Rel-related family members and the genetic responses they promote.

[Indexed for MEDLINE]

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