Format

Send to

Choose Destination
Curr Opin Cell Biol. 1999 Apr;11(2):241-7.

In or out? Regulating nuclear transport.

Author information

1
Harvard Medical School and Dana-Farber Cancer Institute, Smith 922, 44 Binney Street, Boston, MA 02115, USA. jhood@student.med.harvard.edu

Abstract

The compartmentalization of proteins within the nucleus or cytoplasm of a eukaryotic cell offers opportunity for regulation of cell cycle progression and signalling pathways. Nuclear localization of proteins is determined by their ability to interact with specific nuclear import and export factors. In the past year, substrate phosphorylation has emerged as a common mechanism for controlling this interaction.

PMID:
10209150
DOI:
10.1016/s0955-0674(99)80032-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center