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Curr Biol. 1999 Mar 25;9(6):R198-200.

RNA splicing: What has phosphorylation got to do with it?

Author information

1
National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. mistelit@mail.nih.gov

Abstract

Many pre-mRNA splicing factors are phosphorylated in vivo, but the role of this modification has been unclear. Recent observations suggest that phosphorylation modulates protein-protein interactions within the spliceosome, thereby contributing to dynamic structural reorganization of the spliceosome during splicing.

PMID:
10209090
[Indexed for MEDLINE]
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