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Genet Epidemiol. 1999;16(4):337-43.

Method for constructing confidently ordered linkage maps.

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Center for Medical Genetics, Marshfield Medical Research Foundation, WI 54449, USA.


We describe a method for identifying, from a comprehensive genetic map, the most dense framework of confidently ordered markers. The approach uses the number of observed recombination events between each pair of markers, and finds the largest subset of markers for which adjacent loci are separated by at least one recombination. We illustrate the approach using a short region of chromosome 7p.

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