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Bioorg Med Chem Lett. 1999 Mar 22;9(6):831-4.

Ring constrained analogues of the orvinols: the furanomorphides.

Author information

1
School of Chemistry, Cantock's Close, University of Bristol, England.

Abstract

A series of furanomorphides were synthesised as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the mu opioid receptor compared to the orvinols.

PMID:
10206545
DOI:
10.1016/s0960-894x(99)00085-2
[Indexed for MEDLINE]

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