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Breast Cancer Res Treat. 1999 Jan;53(1):87-91.

Male breast cancer in the hereditary nonpolyposis colorectal cancer syndrome.

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1
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. boydj@mskcc.org

Abstract

A male member of a large HNPCC kindred, affected by primary malignancies of the breast and colon, was identified. This individual was found to harbor a germline mutation of the MLH1 mismatch repair gene previously shown to segregate with disease in this kindred. The breast tumor exhibited somatic reduction to homozygosity for the MLH1 mutation, and microsatellite instability was evident in the breast tumor. We conclude that hereditary male breast cancer can occur as an integral tumor in the HNPCC syndrome.

PMID:
10206076
[Indexed for MEDLINE]
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