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Trends Microbiol. 1999 Mar;7(3):104-10.

Clostridium perfringens: toxinotype and genotype.

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Centre National de Reference des AnaƩrobies, Institut Pasteur, Paris, France.


Clostridium perfringens is a ubiquitous pathogen that produces many toxins and hydrolytic enzymes. Because the toxin-encoding genes can be located on extrachromosomal elements or in variable regions of the chromosome, several pathovars have arisen, each of which is involved in a specific disease. Pathovar identification is required for a precise diagnosis of associated pathologies and to define vaccine requirements. For these purposes, toxin genotyping is more reliable than the classical toxinotyping.

[Indexed for MEDLINE]

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