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Trends Cell Biol. 1999 Apr;9(4):138-44.

RGS proteins: more than just GAPs for heterotrimeric G proteins.

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Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.


Members of the newly described RGS family of proteins have a common RGS domain that contains GTPase-activating activity for many Galpha subunits of heterotrimeric G proteins. Their ability to dampen signalling via Galphai-, Galphaq- and Galpha12/13-coupled pathways makes them crucial players in mediating the multitude of cellular processes controlled by heterotrimeric G proteins. Some RGS proteins also contain additional motifs that link them to other signalling networks, where they constitute effector-type molecules. This review summarizes recent findings on RGS proteins, especially those that implicate RGS proteins in more than just enhancing the GTPase activity of their Galpha subunit targets.

[Indexed for MEDLINE]

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